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Wilbur B Bowne Selected Research

PNC-27

4/2022PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis.
1/2021Molecular Targeting of H/MDM-2 Oncoprotein in Human Colon Cancer Cells and Stem-like Colonic Epithelial-derived Progenitor Cells.
9/2020Anti-Cancer Tumor Cell Necrosis of Epithelial Ovarian Cancer Cell Lines Depends on High Expression of HDM-2 Protein in Their Membranes.
9/2020Targeting Membrane HDM-2 by PNC-27 Induces Necrosis in Leukemia Cells But Not in Normal Hematopoietic Cells.
1/2015Ex vivo Efficacy of Anti-Cancer Drug PNC-27 in the Treatment of Patient-Derived Epithelial Ovarian Cancer.
1/2014The anti-cancer peptide, PNC-27, induces tumor cell necrosis of a poorly differentiated non-solid tissue human leukemia cell line that depends on expression of HDM-2 in the plasma membrane of these cells.
7/2010The anti-cancer peptide, PNC-27, induces tumor cell lysis as the intact peptide.
2/2010Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes.

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Wilbur B Bowne Research Topics

Disease

30Neoplasms (Cancer)
06/2024 - 02/2002
9Necrosis
12/2023 - 01/2007
7Pancreatic Neoplasms (Pancreatic Cancer)
10/2023 - 01/2007
5Neoplasm Metastasis (Metastasis)
06/2024 - 02/2002
4Adenocarcinoma
10/2023 - 01/2017
4Colonic Neoplasms (Colon Cancer)
02/2023 - 01/2019
2Disease Progression
06/2024 - 12/2019
2Neoplasms, Cystic, Mucinous, and Serous
03/2024 - 06/2015
2Pseudomyxoma Peritonei
03/2022 - 01/2020
2Leukemia
09/2020 - 01/2014
2Ovarian Epithelial Carcinoma
09/2020 - 01/2015
2Ovarian Neoplasms (Ovarian Cancer)
09/2020 - 01/2015
2Pain (Aches)
08/2018 - 04/2007
1Hepatocellular Carcinoma (Hepatoma)
06/2024
1Carcinoma (Carcinomatosis)
03/2024
1Duodenal Obstruction
06/2023
1Perivascular Epithelioid Cell Neoplasms
04/2023
1Colorectal Neoplasms (Colorectal Cancer)
02/2023
1Diabetic Ketoacidosis (Ketoacidosis, Diabetic)
01/2023
1Pancreatic Fistula (Pancreatic Fistulas)
01/2023
1Teratoma (Teratoid Tumor)
03/2022
1Acute Myelomonocytic Leukemia
09/2020
1Acute Monocytic Leukemia (Acute Monoblastic Leukemia)
09/2020
1Acute Promyelocytic Leukemia
09/2020
1Hematologic Neoplasms (Hematological Malignancy)
09/2020
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
09/2020
1Sarcoma (Soft Tissue Sarcoma)
01/2020
1Gastrinoma
12/2019
1Carcinoid Tumor (Carcinoid)
12/2019
1Peptic Ulcer (Peptic Ulcers)
12/2019
1Zollinger-Ellison Syndrome (Syndrome, Zollinger-Ellison)
12/2019
1Shock
01/2019

Drug/Important Bio-Agent (IBA)

11Peptides (Polypeptides)IBA
02/2023 - 01/2007
8PNC-27IBA
04/2022 - 02/2010
6Proteins (Proteins, Gene)FDA Link
02/2023 - 01/2007
3L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
01/2014 - 07/2008
2Cell-Penetrating PeptidesIBA
02/2023 - 04/2022
2VaccinesIBA
11/2021 - 08/2018
2Annexin A5IBA
01/2021 - 12/2008
2MucinsIBA
01/2020 - 02/2018
2AntigensIBA
08/2018 - 02/2002
2PNC-28IBA
01/2015 - 12/2008
2penetratinIBA
12/2008 - 01/2007
1lenvatinibIBA
06/2024
1alpha-Fetoproteins (alpha-Fetoprotein)IBA
06/2024
1atezolizumabIBA
06/2024
1GemcitabineFDA Link
06/2024
1Tyrosine Kinase InhibitorsIBA
06/2024
1Oxaliplatin (Eloxatin)FDA LinkGeneric
06/2024
1Bevacizumab (Avastin)FDA Link
06/2024
1Colloids (Colloid)IBA
03/2024
1Mitomycin (Mitomycin-C)FDA LinkGeneric
12/2023
1AnthelminticsIBA
10/2023
1pyrvinium (Vankin)FDA Link
10/2023
1MetalsIBA
06/2023
1Sirolimus (Rapamycin)FDA Link
04/2023
1DesminIBA
04/2023
1MART-1 AntigenIBA
04/2023
1MTOR InhibitorsIBA
04/2023
1adagrasibIBA
02/2023
1Mutant Proteins (Protein, Mutant)IBA
02/2023
1Peptide LibraryIBA
02/2023
1Monoclonal AntibodiesIBA
02/2023
1Cyclic PeptidesIBA
02/2023
1sotorasibIBA
02/2023
1Small Molecule LibrariesIBA
02/2023
13-Hydroxybutyric Acid (beta-Hydroxybutyric Acid)IBA
01/2023
1Insulin (Novolin)FDA Link
01/2023
16-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA
04/2022
1GoldIBA
04/2022
1Cancer VaccinesIBA
11/2021
1Caspase 3 (Caspase-3)IBA
01/2021
1Oncogene Proteins (Oncogene Protein)IBA
01/2021
1Protein Isoforms (Isoforms)IBA
09/2020
1malic acid (malate)IBA
01/2020
1Aspartic Acid (Aspartate)FDA Link
01/2020
1Lactic Acid (Lactate)FDA LinkGeneric
01/2020
1Octreotide (Sandostatin)FDA LinkGeneric
12/2019
1GastrinsIBA
12/2019
1NitrogenIBA
10/2019
1Oxygen (Dioxygen)IBA
10/2019
1Plasma GasesIBA
10/2019
1AlbuminsIBA
01/2019

Therapy/Procedure

12Therapeutics
06/2024 - 02/2002
5Immunotherapy
06/2024 - 08/2018
4Hyperthermic Intraperitoneal Chemotherapy
06/2024 - 02/2018
4Drug Therapy (Chemotherapy)
06/2024 - 01/2015
3Cytoreduction Surgical Procedures
06/2024 - 03/2022
3Neoadjuvant Therapy
03/2024 - 01/2017
3Pancreaticoduodenectomy
01/2023 - 01/2018
2Gastric Bypass (Roux-en-Y Gastric Bypass)
06/2023 - 08/2018
1Patient Readmission
04/2024
1Contraindications
04/2024
1Stents
06/2023
1Precision Medicine
02/2023
1Length of Stay
01/2023
1Salpingo-oophorectomy
03/2022
1Brachytherapy
01/2020
1Subcutaneous Injections
01/2020
1Colectomy
01/2019